Acute Kidney Injury (Contributions to Nephrology, 156) by C. Ronco, R. Bellomo, J.A. Kellum

By C. Ronco, R. Bellomo, J.A. Kellum

Acute kidney damage is outlined as an abrupt swap in serum creatinine and/or urine output, and a majority of sufferers admitted to the ICU have a few proof of the affliction. regrettably, remedy for this complicated syndrome is as but missing and knowing is restricted. An interdisciplinary panel of specialists has contributed to this quantity, illuminating the various basic and complicated features of the illness starting from pathophysiology to therapy, from rising biomarkers to genetic polymorphisms. different contributions concentrate on immunological concerns or the various problems of acute kidney damage and co-morbid stipulations encountered, overlaying the basics in addition to the newest advancements. additionally, vital technical points of extracorporeal treatments together with vascular entry, anticoagulation or fluid composition are brought, and assorted methods to renal help from intermittent dialysis to non-stop remedies and hybrid recommendations are mentioned. an outline of complicated extracorporeal concepts of organ help and their function within the administration of sepsis and acute kidney damage within the context of an total technique of multi-organ failure administration concludes the discussions. This quantity not just presents a pragmatic and up to date precis of present wisdom and expertise, but in addition imparts a primary realizing of the pathogenesis and sure destiny advancements during this box. It additionally serves to problem and re-evaluate the elemental underlying assumptions we carry relating to severe disease ordinarily and acute kidney harm particularly.

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Extra resources for Acute Kidney Injury (Contributions to Nephrology, 156)

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Xue JL, Daniels F, Star RA, Kimmel PL, Eggers PW, Molitoris BA, Himmelfarb J, Collins AJ: Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol 2006;17:1135–1142. Uchino S, Bellomo R, Goldsmith D, Bates S, Ronco C: An assessment of the RIFLE criteria for acute renal failure in hospitalized patients. Crit Care Med 2006;34:1913–1917. Hoste EA, Clermont G, Kersten A, Venkataraman R, Angus DC, De Bacquer D, Kellum JA: RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis.

Brivet FG, Kleinknecht DJ, Loirat P, et al: Acute renal failure in intensive care units – causes, outcome, and prognostic factors of hospital mortality: a prospective, multicenter study. French Study Group on Acute Renal Failure. Crit Care Med 1996;24:192–198. Uchino S, Kellum JA, Bellomo R, et al: Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005;294:813–818. Neveu H, Kleinknecht D, Brivet F, et al: Prognostic factors in acute renal failure due to sepsis: results of a prospective multicenter study.

Lassnigg A, Schmidlin D, Mouhieddine M, Bachmann LM, Druml W, Bauer P, Hiesmayr M: Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study. J Am Soc Nephrol 2004;15:1597–1605. Bellomo R, Kellum J, Ronco C: Acute renal failure: time for consensus. Intensive Care Med 2001;27:1685–1688. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P; ADQI workgroup: Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.

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