Animal Models of Drug Addiction by Robert B. Stewart, Larry A. Grupp (auth.), Alan A. Boulton,

By Robert B. Stewart, Larry A. Grupp (auth.), Alan A. Boulton, Glen B. Baker, Peter H. Wu (eds.)

to the Animal types Volumes This quantity describes animal types of drug dependancy. due to expanding public main issue over the moral remedy of animals in learn, we felt it incumbent upon us to incorporate this basic preface in an effort to point out why we expect extra examine utilizing animals is important. Animals should still purely be used whilst compatible choices should not on hand, and people can purely be experimented upon in seriously proscribed conditions. replacement systems utilizing telephone or tissue tradition are insufficient in any versions requiring tests of behavioral swap or of advanced in vivo p- cesses. in spite of the fact that, whilst the misery, soreness, or ache to the animals outweighs the expected earnings for human welfare, the examine isn't moral and shouldn't be performed. it's crucial that every person researcher learn his/ her personal learn from a serious ethical point of view earlier than eng- ing in it, and think about the animals’ welfare in addition to the expected profits. moreover, as soon as a call to p- ceed with study is made, it's the researcher’s accountability to make sure that the animals’ welfare is of major crisis by way of acceptable housing, feeding, and greatest relief of any uncomfortable or distressing results of the experimental conditions.

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1972). Along similar lines, Stewart et al. (1988) attempted to train rats that were not weightreduced to self-administer ethanol using the prandial drinking method. The procedure used was identical to that described for the prandial drinking method except that the rats had ud Zibitum access to food at all times in their home cages, including the Acquisition (training) and Test phases of the experiment. A sweetened dry breakfast cereal was used in place of pelleted chow to induce prandial thirst during drinking trials of the Acquisition phase.

Grupp L. , and Leenen F. H. H. (1989) Alcohol intake is inversely related to plasma renin activity in the genetically selected alcohol-preferring and -non-preferring lines of rats. Phurmcol. Biochem. Be/tav. 32,1061-1063. Alcohol Consumption Models Grupp L. , Wanless I. , and Stewart R. B. (1986a) Voluntary alcohol intake in the hypertension prone Dahl rat. PharmacoZ. B&hem. Behav. 24,1167-1174. Grupp L. , and Stewart R. B. (1986b) Diet and diuretics in the reduction of voluntary alcohol drinking in rats.

PharmacoZ. B&hem. Behav. 24,1167-1174. Grupp L. , and Stewart R. B. (1986b) Diet and diuretics in the reduction of voluntary alcohol drinking in rats. Alcohol and Alcoholism 21,75-79. Henningfield J. E. and Meisch R. A. (1975) Ethanol-reinforced responding and intake as a function of volume per reinforcement. Pharmucol. Biochem. Behav. $437-441. , Dahl L. , and Knudsen K. D. (1973), Genetic influences on the renin-angiotensin system. Low renin activities in hypertension-prone rats. Circ. Res. a2,678-684.

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