Animal Models of Spinal Cord Repair by Pierre A. Guertin (auth.), Håkan Aldskogius (eds.)

By Pierre A. Guertin (auth.), Håkan Aldskogius (eds.)

The improvement of therapy concepts which can aid sufferers with spinal wire damage to regain misplaced services and a stronger caliber of lifestyles is a tremendous scientific problem, and experimental spinal wire learn has to fulfill those demanding situations by way of resolving basic difficulties, developing a foundation for attainable novel therapy innovations of spinal wire harm, and motivating their scientific translation. In Animal types of Spinal twine Repair, professional researchers research a huge diversity of experimental versions for examine on spinal twine damage, how they've got contributed to our present country of information, and what their merits are within the extra development of spinal wire fix. With types from uncomplicated lamprey to non-human primates, the knowledge awarded is meant to lead the implementation of animal types for spinal wire fix in addition to to elevate the notice of the relevance of experimental versions that can now not be within the present mainstream of this learn. As part of the Neuromethods sequence, this paintings includes the type of distinctive description and implementation suggestion to assure winning leads to the laboratory.

Comprehensive and state-of-the-art, Animal versions of Spinal twine Repair offers the historical past details and hands-on equipment descriptions, in addition to the elemental and scientific matters, had to stimulate and consultant researchers with assorted backgrounds in the direction of the improvement of greater thoughts for functionally correct fix of the injured human spinal cord.

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The manner in which this pattern of damage develops is unknown, although a variety of vascular mechanisms have been proposed (57–59). Quencer and colleagues (60) have suggested, in a correlative MRI pathological study, that hyperextension-associated buckling of the ligamenta flava into a spinal canal that has already been narrowed by cervical spondylosis may lead to axonal disruption at the sites indicated above. 6. Concluding Remarks The anatomical distribution of the lesions within the traumatized spinal cord will be determined by the manner in which the injury is sustained and will, in turn, determine the resulting signs and symptoms.

If the damage to the spinal cord parenchyma is extensive, the collagen may encroach upon what remains of the parenchyma to such an extent that it appears to replace it completely (Fig. 6). The collagen is presumably elaborated by arachnoidal cells and is limited to the subarachnoid compartment, as evidenced by the presence of a layer of arachnoidal cells between the mass of collagen and the dura (37) (Fig. 7). A recent study in experimental animals suggests that pericytes may also contribute to the appearance of collagen (38).

Yu YL, du Boulay GH, Stevens JM, Kendall BE (1986) Computer-assisted myelography in cervical spondylotic myelopathy and radiculopathy: clinical correlations and pathogenetic mechanisms. Brain 109(2):259–278 53. Bedford PD, Bosanquet FD, Russell WR (1952) Degeneration of the spinal cord associated with cervical spondylosis. Lancet 260(6724):55–59 54. Brain WR, Northfield D, Wilkinson M (1952) The neurological manifestations of cervical spondylosis. Brain 75(2):187–225 55. Mair WGP, Druckman R (1953) The pathology of spinal cord lesions and their relation to the clinical features in protrusion of cervical intervertebral discs (a report of four cases).

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