Background Lesions in Laboratory Animals. A Color Atlas by Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath

By Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath

Background Lesions in Laboratory Animals should be a useful relief to pathologists wanting to acknowledge heritage and incidental lesions whereas interpreting slides taken from laboratory animals in acute and protracted toxicity reviews, or whereas reading unique species in a diagnostic laboratory. It provides transparent descriptions and illustrations of the vast majority of history lesions more likely to be encountered. the various lesions lined are strange and will be wrong for treatment-related findings in preclinical toxicity studies.

The Atlas has been ready with contributions from skilled toxicological pathologists who're experts in all the laboratory animal species lined and who've released generally in those areas.

  • over six hundred high-definition, most suitable colour pictures of history lesions present in rats, mice, canine, minipigs, non-human primates, hamsters, guinea pigs and rabbits
  • a separate bankruptcy on lesions within the reproductive structures of all laboratory animals written by means of Dr Dianne Creasy, a global specialist on testicular lesions in laboratory animals
  • a bankruptcy on universal artifacts that could be saw in histological glass slides
  • extensive references to every lesion described
  • aging lesions encountered in all laboratory animal species, really in rats in mice that are used for carcinogenicity studies

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Extra resources for Background Lesions in Laboratory Animals. A Color Atlas

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89). Occasional enlarged, hypertrophic renal tubules are observed within the rat renal cortex (Fig. 90). Hyperplasia of the rat transitional epithelium lining the kidney pelvis, often accompanied by vascular ectasia, is observed in the older rat kidney (Fig. 91). Mineralization of the transitional epithelium of the rat kidney pelvis may also be observed in older rats (Fig. 92). A unique form of autolysis is occasionally observed in the kidney of the Wistar rat and may cause confusion in carcinogenicity studies if it is mistaken for a treatment-related finding (Fig.

45 Cyst lined by ciliated epithelium in the nonglandular stomach of the rat. ×200. Iatrogenic gavage injury is not a background change as such, but is commonly encountered in rats. Gavage injuries include esophagitis, pleuritis, periesophageal abscessation and fibrosis (Bertram et al 1996). Cystic dilatation of gastric glands (Fig. 46) is a common finding in the rat stomach. The lesion is not accompanied by inflammation or any other deleterious lesions. Gastric erosion and ulceration of the glandular or non-glandular stomach (Fig.

Oral cavity, esophagus, and stomach. , et al. ), Pathology of the Fischer rat. Academic Press, San Diego, pp. 9–29. , 1978. Pathology of aging rats. CRC Press, West Palm Beach, FL. , 1992. Spontaneous neoplasms in aged control Fischer 344 rats. Cancer Lett. 62, 49–56. , 1995. Non-proliferative changes of the liver, exocrine pancreas and salivary glands of the rat. In: GI-2 guides for toxicologic pathology. STP/ARP/ AFIP, Washington DC. , 1995. Incidence of nonneoplastic lesions in historical control male and female Fischer-344 rats from 90-day toxicity studies.

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