Bacteriophage Applications - Historical Perspective and by Jessica Nicastro, Shirley Wong, Zahra Khazaei, Peggy Lam,

By Jessica Nicastro, Shirley Wong, Zahra Khazaei, Peggy Lam, Jonathan Blay, Roderick A. Slavcev

This e-book explores key functions of phage biotechnology and reports contemporary advances in phage reveal applied sciences. The purposes lined have been chosen at the foundation in their importance and representativeness within the box.

The small dimension and large range of bacteriophages lead them to perfect applicants for varied purposes throughout many industries. because the discovery of phages and the appearance of phage demonstrate structures, massive awareness has been serious about the advance of novel healing and business purposes. contemporary reports mix the genomic flexibility of phages with phage show platforms so one can generate converted phages for special delivery.

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2005; Frenkel and Solomon 2002) and may therefore be exploited for CNS drug and gene delivery. Drug addiction is an important health and social problem world-wide, a prevailing culprit of which is the highly addictive recreational drug cocaine. It has been previously shown that protein-based therapeutics designed to bind to cocaine can reduce the drug load and attenuate its psychoactive effects. However, this strategy has not generally demonstrated significant therapeutic value due to the inability of these cocaine-binding proteins to cross the BBB and gain access to the CNS.

Alternatively, the addition of polyethylene glycol (PEG) can also improve phage circulation (Kim et al. 2008). While the simplicity of phages positions them as attractive cloning vectors, they are generally limited by the size of the gene(s) of interest that can be cloned into the phage head, and in most cases lack natural nuclear honing and expression abilities in eukaryotic cells (Clark et al. 2011; Larocca and Baird 2001). While filamentous bacteriophage have a far more flexible packaging minimum and maximum (Specthrie et al.

Hubbell, J. A. (1992). Surface-immobilized polyethylene oxide for bacterial repellence. Biomaterials, 13(7), 417–420. Donlan, R. M. (2001). Biofilms and device-associated infections. Emerging Infectious Diseases, 7(2), 277–281. Donlan, R. M. (2009). Preventing biofilms of clinically relevant organisms using bacteriophage. Trends in Microbiology, 17(2), 66–72. , Rosdahl, V. , & Skinhøj, P. (1994). Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreign body infection.

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