Behavioral Neurobiology of Bipolar Disorder and its by Philip B. Mitchell, Dusan Hadzi-Pavlovic (auth.), Husseini

By Philip B. Mitchell, Dusan Hadzi-Pavlovic (auth.), Husseini K. Manji, Carlos A. Zarate Jr. (eds.)

Despite the devastating influence of bipolar disease at the lives of thousands all over the world, many elements of its underlying etiology and pathophysiology stay unknown. This ebook, which has assembled a broadly revered team of preclinical and medical researchers, acts as a useful and well timed source for either researchers and clinicians. This quantity studies the very most modern organic, psychopharmacological, and healing literature that has ruled the sector in recent times and contains state-of-the-art translational study. Early chapters evaluate the direction and final result and genetics of this hugely heritable , together with chapters on epigenetics and scientific endophenotypes. a number of chapters supply a remarkably thorough and exact evaluation of the neurobiology of the sickness, together with what's recognized from genetics, molecular neurobiology, neuroimaging, and the improvement of animal types. ultimately, the publication covers remedy thoughts for bipolar sickness, together with either conventional and novel therapeutics, in addition to non-pharmacological remedies. This ebook bargains the original merits of mixing in-depth assurance of present medical wisdom with functional scientific suggestion and a useful eye towards the way forward for the field.

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Extra info for Behavioral Neurobiology of Bipolar Disorder and its Treatment

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2009; Rosell et al. 2009). 3 Bipolar Disorder: The Epigenetic Perspective The epigenetic model of BPD and other complex diseases relies on three fundamental concepts formed from experimental observations: Understanding Bipolar Disorder: The Epigenetic Perspective 35 1. The spatiotemporal epigenetic regulation of gene function is highly dynamic. The epigenetic makeup of a cell is influenced by the organism’s developmental program, internal and/or external milieu, and stochastic factors (Riggs et al.

2 Novel Molecular Tools . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Novel Analytical Tools . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 5 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

1 Twin Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Family Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 3 Molecular Genetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Genetic Linkage and Candidate Gene Studies . . . .

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