Bioactive Peptides by John Howl, Sarah Jones

By John Howl, Sarah Jones

Focuses on Biology, Pharmacology, and healing Applications

The research and various functions of bioactive peptides traverse many sub-disciplines inside chemistry, biology, physics, and medication. Answering a long-standing want, Bioactive Peptides makes a speciality of the biology, pharmacology, and healing purposes of endogenous peptide mediators and their analogues. relocating peptide technology past chemical synthesis innovations and into the nation-states of peptide biology and therapeutics, it offers the final contribution that peptide technology has made to molecular, mobile, and entire organism biology, whereas additionally discussing destiny pursuits and healing applications.

Beneficial for specialists and beginners Alike

Part I offers info of bioactive peptides that engage with universal drug objectives and analyzes the most aggressive components of present learn around the world. whereas it's widely recognized that mammalian physiological structures make the most of bioactive peptides that experience but to be found, different animals supply a wealthy and beneficial resource of bioactive peptides. This attention-grabbing zone of technological know-how is the subject matter of half II. Parts III and IV examine the original bioactivities of assorted peptides which are ripe for extra exploration.

This definitive reference additionally includes:

  • A unique description and research of a extensive diversity of peptides that engage with G protein-coupled receptors, the quantitatively dominant drug target
  • A dialogue of non-ribosomal peptides, which carry promise as resources of endogenous mediators
  • Important examples of universal methodologies hired to spot, signify, and additional enhance bioactive peptides from a number of traditional sources

With mounting world wide curiosity of their healing power, bioactive peptides—including the id of recent species, the synthesis of structural analogues, and numerous functions in biology and medicine—will most probably stay on the vanguard of medical pastime for plenty of many years. offering even informal readers with a large style of the character and functions of peptides, this quantity draws and excites tomorrow’s researchers who're charged with additional constructing and enforcing the findings provided herein.

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Extra resources for Bioactive Peptides

Example text

Katafuchi, T. , Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. Its isolation from porcine brain, structure, tissue distribution, and biological activity, J. Biol. , 278, 12046–12054, 2003a. , Identification of second and third calcitonin receptor-stimulating peptides in porcine brain, Biochem. Biophys. Res. , 308, 445–451, 2003b. Katafuchi, T. , Isolation and characterization of a glycine-extended form of calcitonin receptor-stimulating peptide-1: Another biologically active form of calcitonin receptor-stimulating peptide-1, Peptides, 26, 2616–2623, 2005.

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Comparison of the effects of calcitonin gene-related peptide and amylin on osteoblasts, J. Bone Miner. , 14, 1302–1309, 1999. Cuifen, Z. , Changes and distributions of peptides derived from proadrenomedullin in left-to-right shunt pulmonary hypertension of rats, Circ. , 72, 476–481, 2008. T. , Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene, Mol. Cell. , 26, 2511–2518, 2006. Dacquin, R. , Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo, J.

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