By R. H. M. Goossens (auth.), Amit Gefen (eds.)
Pressure-related persistent wounds are a massive future health trouble that is affecting hundreds of thousands of sufferers and accumulates billions in annual expenses. those wounds may perhaps take place while delicate tissues are routinely compressed among bony prominences and a assisting floor. This booklet supplies an entire and quantitative clarification of the mechanobiology which motives continual wounds. The studies provide an total photo on all size scales of the phenomenon, ranging from musculoskeletal biomechanics to the modeling of sentimental tissues and their interplay with bones. on the microscopic degrees, it completely studies experiments and modeling of mobile forces and molecular strategies that happen in the course of damage and therapeutic, together with the integrity of residing cells subjected to sustained mechanical forces and deformations. the implications enable a whole photo of the tolerance of human tissues to sustained quite a bit, and an figuring out of the chance for onset of persistent wounds. for that reason, this publication is additionally priceless for all pros excited by the prevention and therapy of persistent wounds.
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Additional info for Bioengineering Research of Chronic Wounds: A Multidisciplinary Study Approach
Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J. Cell. Sci. : Animal models of keloids and hypertrophic scars. J. Burn. Care Res. : Postoperative electron-beam irradiation therapy for keloids and hypertrophic scars: retrospective study of 147 cases followed for more than 18 months. Plast. Reconstr. Surg. : Keloid and hypertrophic scarring may result from a mechanoreceptor or mechanosensitive nociceptor disorder. Med. : Mechanical load enhances procollagen processing in dermal fibroblasts by regulating levels of procollagen C-proteinase.
P. Orgill1 B. Normal Tissue and Cellular Response of Skin Against Mechanical Forces With respect to mechanotransduction studies of human dermal fibroblasts in vitro, (Parson et al. 1999) reported that procollagen synthesis and procollagen mRNA levels were increased after 48hour of cyclic 20% strain, and the response was increased in presence of transforming growth factor-β1 (TGF-β1). Kessler et al. 2001) also studied human dermal fibroblasts those were cultured within 3-D gels under application of tension.
1993, Wu et al. 1 and 2). As a result, cell proliferation, angiogenesis and epithelization are accelerated. In addition to these cellular responses, macro-scale tissue response from mechanical stimuli including hypoxia is also closely related to wound healing. 1. Schema of Cellular Mechanoreceptors (Mechanosensors) in The Skin Mechanobiology of Cutaneous Wound Healing and Scarring 33 Fig. 2. Schema of Mechanical Forces and Cellular Responses A. Tensile force B. Shear force C. g. stretching tension, shear force, osmotic pressure, and hydrostatic pressure, and cells convert these mechanical stimuli into electrical signals through mechanoreceptors (mechanosensors) such as mechanosensitive ion channels, cell adhesion molecules including integrins, and actin filaments in the cytoskeleton.