BSAVA Manual of Canine and Feline Wound Management and by David Fowler, John M. Williams

By David Fowler, John M. Williams

Guide of canines and pussycat wound administration and reconstruction КНИГИ ;ЕСТЕСТВЕННЫЕ НАУКИ Название: guide of dogs and pussycat wound administration and reconstruction Автор: Fowler D., Williams J.M. Издательство: BSAVA Год: 1999 Страниц: a hundred and sixty Формат: pdf Размер: sixteen mb Язык: English Краткое описание книги: Руководство по эстетической и пластической хирургии собак и кошек.Скачать c Скачать c zero

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Tissues must be handled gently to prevent further vascular injury and an increased inflammatory response. Control of haemorrhage reduces the risk of systemic complications secondary to hypovolemia, reduces the risk of postoperative infection, and diminishes the incidence of haematoma and seroma formation. Accurate identification of tissue layers and precise apposition of tissues reduce the incidence of dehiscence and improve the quality and cosmetic result of the reconstruction. All wound edges, following surgical debridement, should be vertical, to allow true apposition with minimal scar formation.

The increased survival of the flaps on rats that had received L-arginine was attributed to vasodilation induced by nitric oxide; thus, arterial vasospasm was reduced preserving perfusion in the distal aspects of the random pattern flaps. L-Arginine was also administered to rats receiving growth factors. In combination, L-arginine and growth factors, and in particular TGF-p\ significantly increased flap survival. This approach to augmenting nitric oxide levels following or prior to wounding may have application in several clinical situations.

Also, MPA has been shown to inhibit FGF-stimulated DNA synthesis in smooth muscle cells. By itself, MPA reduces arterial intimal thickening following both mechanical and immune-mediated injury. RPM com­ bined with MPA was the most effective antiproliferative agent tested in our laboratories. The different mecha­ nisms of action appear to combine to produce a very effective antiproliferative effect. Leflunomide This is known as LEF. It is a synthetic organic isoxazole derivative that is metabolized to the active form, A77 1726.

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