Cell adhesion and communication mediated by the CEA family : by Clifford P Stanners

By Clifford P Stanners

Considers the hot explosion of information in regards to the carcinoembryonic antigen (CEA) kinfolk, which resulted from the molecular cloning of friend genes in 1986.
Results indicating CEA kinfolk upregulated in melanoma can have an instrumental position in malignant transformation and metastasis, whereas those who are downregulated can have tumor suppressive capabilities are thought of. experiences, fresh effects, hypotheses, and medical purposes relating to a gene family members that, from its frequent adjustments in expression in tumors at many websites, may be considered as a "major participant" in human melanoma also are mentioned. the conventional features corresponding to epithelial and hematopoietic adhesion and signalling molecules are explored, and the potentially exact function of this kin in evolution is brought.
This quantity may be of curiosity to researchers within the fields of intercellular adhesion, evolution, and molecular acceptance, in addition to clinicians drawn to the new wisdom concerning a tumor marker as a rule utilised within the sanatorium, and corporations wishing to take advantage of this cancer-related kinfolk for novel advertisement purposes within the biomedical sphere.

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Internat. , 5, 265–270. L. F. (1992) Expression of carcinoembryonic antigen and related genes in lung and gastrointestinal cancers. Int. J. Cancer, 52, 718–725. Kimura, M. (1983) The neutral theory of molecular evolution, Cambridge Univ. Press, London. , Nakashima, I. and Taakagi, H. (1993) Expression of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in gastrointestinal cancer; the correlation with degree of differentiation. Br. J. Cancer, 68, 130–136. , Grunert, F. and Roos, D.

E. (1988) Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen. J. Biol. , 263, 3202–3207. , Matthaes, P. and Wagener, C. (1993) Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc. Natl. Acad. Sci. USA, 90, 10744–10748. HAMMARSTRÖM ET AL. -H. and Barrels, I. 1. Cytogenet. Cell Genet. 52, 95–97. , Nagaoka, I. and Kira, S. (1994) Biliary glycoprotein mRNA expression is increased in primary lung cancer, erspecially in squamous cell carcinoma.

Res. , 166, 1063– 1071. , Slezak, T. V. (1995) An Integrated, Metric Physical Map of Human Chromosome 19. Nature Genetics 11, 422–427. M-W. and Hammarström, S. (1994) Expression of carcinoembryonic antigen and nonspecific cross-reacting 50 kDa antigen in human normal and cancerous colon mucosa: comparative ultrastructural study with monoclonal antibodies. , 54, 3305– 3314. A. J. (1988) Carcinoembryonic antigen family: Characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains.

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