Cell Junctions: Adhesion, Development, and Disease by Susan E. La Flamme, Andrew P. Kowalczyk

By Susan E. La Flamme, Andrew P. Kowalczyk

“This quantity offers a great evaluate into the area of telephone adhesion. It offers vital information about the most gamers in all points of phone junctions.” –The Quarterly assessment of Biology, September 2009

Eagerly awaited, this finished publication on a subject of primary value in our realizing of melanoma starts with an summary of mobile junctions, sooner than protecting intimately cell-matrix junctions, cell-cell junctions besides as cell-matrix and cell-cell adhesion. This reference work is of excessive curiosity to cellphone and molecular biologists, melanoma researchers, oncologists, biochemists, pharmaceutists and people operating within the pharmaceutical undefined.

Show description

Read or Download Cell Junctions: Adhesion, Development, and Disease PDF

Similar cell biology books

Acute Kidney Injury (Contributions to Nephrology, 156)

Acute kidney harm is outlined as an abrupt swap in serum creatinine and/or urine output, and a majority of sufferers admitted to the ICU have a few facts of the disease. regrettably, remedy for this complicated syndrome is as but missing and realizing is restricted. An interdisciplinary panel of specialists has contributed to this quantity, illuminating the various primary and complicated features of the affliction starting from pathophysiology to remedy, from rising biomarkers to genetic polymorphisms.

Evolution equations and their applications in physical and life sciences

This quantity offers a suite of lectures on linear partial differntial equations and semigroups, nonlinear equations, stochastic evolutionary methods, and evolution difficulties from physics, engineering and mathematical biology. The contributions come from the sixth overseas convention on Evolution Equations and Their purposes in actual and lifestyles Sciences, held in undesirable Herrenalb, Germany.

Nitric oxide: principles and actions

This certain sourcebook serves as a entire reference, bridging the well-established chemistry of nitric oxide and the recent and intriguing function of nitric oxide as an effector and signaling molecule in several organic platforms. Nitric Oxide: ideas and activities relates the chemical houses of the molecule to its attainable results on organic platforms, below either common physiological and pathophysiological stipulations.

Ciba Foundation Symposium 164 - Interactions Among Cell Signalling Systems

A panel of the world over well known specialists current papers on mobilephone signalling--an zone within which there was fresh vital advances. assurance contains the inositol 1, four, 5-triphosphate receptor, signal-induced phospholipid degradation cascade and protein kinase C activation, cyclic AMP interactions in sustained mobile reaction, the acetylcholine receptor and lots more and plenty extra.

Extra info for Cell Junctions: Adhesion, Development, and Disease

Example text

2 Connecting agonist stimulation to integrin activation; the core connections between agonists and integrins are depicted. , G-protein-coupled receptors, tyrosine-kinase-coupled receptors) induce the formation of diacylglycerol (DAG) and increased Ca2+, leading to the activation and/or translocation of active GTP- bound Rap1 to the plasma membrane via activation of protein kinase C (PKC) or a Rap guanine nucleotide exchanger (Rap-GEF). At the plasma membrane, activated Rap interacts with Rap1−GTP-interacting adaptor molecule (RIAM), leading to the recruitment of talin to form the integrin activation complex, thus unmasking the integrin binding site on talin, and leading to integrin activation.

Dev. Cell 7, 585–595. , Lim, C. , Calderwood, D. , Lafuente, E. , Boussiotis, V. , Shattil, S. , and Ginsberg, M. H. (2006) Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr. Biol. 16, 1796–1806. 98 O’Toole, T. , Loftus, J. , Du, X. , Glass, A. , Ruggeri, Z. , Shattil, S. , Plow, E. , and Ginsberg, M. H. (1990) Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regul. 1, 883–893. References 99 Xiong, J.

Hughes et al. found that H-Ras and its downstream effector kinase, Raf-1, suppress integrin activation in CHO cells, which is independent of de-novo protein synthesis and integrin phosphorylation and is mediated by the activation of the 13 14 1 The Ins and Outs of Integrin Signaling ERK1/2 MAP kinase pathway [89, 90]. However, this suppression of integrin affinity by H-Ras is cell-type specific for, unlike in CHO cells and fibroblasts, H-Ras can promote integrin activation in other cell types such as certain hematopoietic cell lines [89].

Download PDF sample

Rated 4.02 of 5 – based on 6 votes