Cellular Rhythms and Networks: Implications for Systems by Qing Yan

By Qing Yan

​This e-book presents an summary of circadian rhythms and mobile networks of their relation to organic structures and dynamical drugs. Six concise chapters discover circadian mobilephone rhythms and biomarkers in irritation, heart problems, melanoma, melancholy, and extra in inflicting and treating those illnesses. the ultimate bankruptcy discusses optimization of drug supply and individualized therapy structures utilizing chronotherapy and chronobiology-based biomarkers as a basic procedure of drugs. Succinct but accomplished, mobile Rhythms and Networks, a part of SpringerBriefs in mobilephone Biology offers a singular framework for scientific functions in customized and structures medication. it's valuable studying for researchers and clinicians in phone biology, temper problems, and structures medicine.

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Extra resources for Cellular Rhythms and Networks: Implications for Systems Medicine

Example text

In the following sections, the circadian–immune crosstalk and systemic inflammatory factors will be discussed in various diseases. 1 Lung Disorders Patients with lung disorders such as obstructive lung diseases often have abnormal circadian patterns in the lung functions (Hwang et al. 2014). As the immune functions are regulated by circadian rhythms, inflammatory lung diseases often show circadian alterations in symptom seriousness. Local and systemic circadian clocks may interact with each other in both physiological and pathological conditions.

The circadian-associated factors can be affected by immune challenges at different temporal, genetic, and tissue-specific scales, as well as by body temperature at the organismal level (Cermakian et al. 2014). A broad spectrum of rhythmically regulated humoral elements may be associated with the inflammatory pathways, including glucocorticoids, prostaglandins, melatonin, and leptin. Other factors also have critical roles, such as the neuronal associations between the brain and peripheral tissues, as well as the rhythmic activities of cytokines and their receptors (Cermakian et al.

Genome Biol 6:219 Hoffman AE, Zheng T, Ba Y, Stevens RG, Yi C-H, Leaderer D, Zhu Y (2010) Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways. BMC Cancer 10:110 Hogenesch JB, Ueda HR (2011) Understanding systems-level properties: timely stories from the study of clocks. Nat Rev Genet 12:407–416 Hsuchou H, Wang Y, Cornelissen-Guillaume GG, Kastin AJ, Jang E, Halberg F, Pan W (2013) Diminished leptin signaling can alter circadian rhythm of metabolic activity and feeding.

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