Childhood Obesity: Prevalence, Pathophysiology, and by Rexford S. Ahima

By Rexford S. Ahima

This identify incorporates a variety of Open entry chapters.

The occurrence of formative years obese and weight problems has elevated around the world in contemporary a long time. weight problems in adolescence is linked to a variety of critical future health issues and an elevated threat of untimely disorder and demise later in existence. This ebook provides formative years weight problems developments throughout a number of demographics and discusses the contributing genetic and environmental components. It demonstrates the hostile well-being results of formative years weight problems either as they relate to early life and as they final into maturity and offers a number of tools for weight problems therapy incorporated neighborhood and family-based intervention, pharmacotherapy, and surgical procedures.

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80. R. J. Loos, I. Barroso, S. O'rahilly, and N. J. Wareham, “Comment on “A common genetic variant is associated with adult and childhood obesity”,” Science, vol. 315, no. 5809, p. 187, 2007. 81. C. Dina, D. Meyre, C. , “Comment on “A common genetic variant is associated with adult and childhood obesity”,” Science, vol. 315, no. 5809, p. 187, 2007. Genetics of Childhood Obesity 19 82. D. Rosskopf, A. Bornhorst, C. , “Comment on “A common genetic variant is associated with adult and childhood obesity”,” Science, vol.

To complement these previous CNV studies on extreme obesity, we addressed CNVs in common childhood obesity by examining children in the upper 5th percentile of BMI but excluding any subject greater than 3 standard deviations from the mean to reduce severe cases in the cohort [104] (Table 1). We performed a whole–genome CNV survey of our cohort of European American (EA) childhood obesity cases (n = ~1,000) and lean controls (n = 2,500) who were genotyped with 550,000 SNP markers. We identified 34 putative CNVR loci (15 deletions and 19 duplications) that were exclusive to EA cases; however, three of the deletions proved to be false positives during the validation process with quantitative PCR (qPCR).

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