Ciba Foundation Symposium 109 - Mucus and Mucosa

Chapter 1 advent (pages 1–3): A. Silberberg
Chapter 2 legislation of Secretion from Serous and Mucous Cells within the Trachea (pages 4–19): C.B. Basbaum
Chapter three rules of Intestinal Goblet Cells in situ, in Mucosal Explants and within the remoted Epithelium (pages 20–39): Marian R. Neutra, Teresa L. Phillips and Thomas E. Phillips
Chapter four Airway Mucus: Composition and rules of its Secretion via Neuropeptides in vitro (pages 40–60): Stephen J. Coles, okay. R. Bhaskar, Donna Defeudis O'Sullivan, Kenneth H. Neill and Lynne M. Reid
Chapter five Acute and protracted types for Hypersecretion of Intestinal Mucin (pages 61–71): J. Forstner, N. Roomi, R. Fahim, G. Gall, M. Perdue and G. Forstner
Chapter 6 Proteinases free up Mucin from airlines Goblet Cells (pages 72–93): Thomas F. Boat, Pi Wan Cheng, Jeffrey D. Klinger, Carole M. Liedtketi and Bernard Tandler
Chapter 7 a few features of Duodenal Etithelium (pages 94–108): Gunnar Flemstrom and Andrew Garner
Chapter eight Fluid shipping throughout Airway Epithelia (pages 109–120): J. H. Widdicombe
Chapter nine a few Non?Mucin elements of Mucus and their attainable organic Roles (pages 121–136): John R. Clamp and J. Michael Creeth
Chapter 10 Mucus Glycoprotein constitution, Gel Formation and Gastrointestinal Mucus functionality (pages 137–156): Adrian Allen, David A. Hutton, Jeffrey P. Pearson and Lynda A. Sellers
Chapter eleven Macromolecular homes and Polymeric constitution of Mucus Glycoproteins (pages 157–172): Ingemar Carlstedt and John ok. Sheehan
Chapter 12 results of the Anti?Oestrogens, Clomiphene and Tamoxifen, at the Cervical consider woman Infertility (pages 173–179): Max Elstein and Gillian M. Fawcett
Chapter thirteen Terminal Glycosylation in Human Cervical Mucin (pages 180–195): E. N. Chantler and P. R. Scudder
Chapter 14 Comparative reports of Mucus and Mucin Physicochemistry (pages 196–211): Mitchell Litt
Chapter 15 Hydration Kinetics of Exocytosed Mucins in Cultured Secretory Cells of the Rabbit Trachea: a brand new version (pages 212–234): Pedro Verdugo
Chapter sixteen last feedback (pages 235–236): A. Silberberg

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Extra info for Ciba Foundation Symposium 109 - Mucus and Mucosa

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Development of the secretory response Because of the continuous renewal of the intestinal epithelium, goblet cells are continuously migrating from the crypts to the mucosal surface or villi. While they are in the crypts they complete their structural differentiation, secrete mucin at baseline rates, and respond to cholinergic secretagogues with rapid mucin release, a response that is blocked by atropine (Specian & Neutra 26 NEUTRAETAL 1982a). As the goblet cells move out of the crypt, they continue to secrete at baseline rates but they cease to respond to cholinergic stimulation.

1) and portions of the limiting membranes of adjacent granules are always closely apposed (Neutra 6t Schaeffer 1977). Rapid secretion of many granules may thus be accomplished by sequential fusion of granule membranes, without the need for granule movement (Figs. 2 and 3 ) . Our studies demonstrated that the rapid secretory response to cholinergic agents is not inhibited by prior treatment of the mucosa with drugs that interfere with polymerization of microtubules. On the other hand, functional microtubules may play a role in the slow transport of mucin granules from the site of their formation in the supranuclear region towards the luminal cell surface under baseline condi- FIG.

Nudef: The differential response of goblet cells to carbachol provides some interesting possibilities in terms of cell-to-cell interactions. A key question is whether there are muscarinic receptors o n all of the goblet cells. This is easy to investigate in a preparation of this size. Muscarinic receptors may be present on crypt goblet cells but not on cells from villi or mucosal surfaces; this would suggest that the goblet cells lose their receptors as they migrate out of the crypts. The second possibility is that the receptors are present but not functional on goblet cells located in the villi.

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