Ciba Foundation Symposium 157 - Clinical Applications of by CIBA Foundation Symposium

By CIBA Foundation Symposium

TGF-beta, initially pointed out as a reworking development issue with related homes, is referred to now to exist as a family members of things with related homes. those components advertise mobile proliferation in a few tissue kinds or stipulations and result in phone differentiation in others. gains the newest info at the TGF-beta family members and its receptors. Describes correlations among TGF-beta and sure cancers, together with glioblastomas. additionally includes stories of initial investigations of scientific purposes for TGF-beta in lots of illnesses, together with leukemia and its use to speed up wound therapeutic.

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The binding parameters vary because the dissociation constants range from 1 pM to 60 pM. There may be as few as 200 or as many as 100 000 receptors per cell, depending on the cell type. Several cell surface proteins that specifically bind TGF-PI and TGF-P2 have been characterized as putative receptors and have been classified on the basis of their size. Type I receptors have an M, of approximately 50 OOO, type I1 receptors an M , of approximately 80 OOO. Both type I and I1 receptors are glycoproteins and TGF-P-induced responses appear to be mediated by one or both types.

Soluble receptors have been found in other fields, particularly for lymphokines: IL-2, IL-4, IL-7 and IL-8. More importantly, the soluble receptors for IL-4 and IL-7 have had immunosuppressive effects in vivo, in pre-clinical studies. Moses: I would suggest that we call betaglycan a binding protein. A receptor cannot be soluble, according to the commonly accepted definition. We might reasonably think of the betaglycan as perhaps analogous to the IGF-I binding protein which has been well characterized by a number of groups, particularly Clemmons’ group (Elgin et a1 1987).

Science (Wash DC) 240: 196- 199 Kyprianou N , Isaacs JT 1988 Identification of a cellular receptor for transforming growth factor-@in rat ventral prostate and its negative regulation by androgens. J Cell Physiol 129:159-166 Like B, Massague J 1986 The antiproliferative effect of type @ transforming growth factor occurs at a level distal from receptors for growth activating factors. J Biol Chem 261~13426-13429 40 Segarini Mar hovac J, Goldstein G W 1988 Transtorrriiiig growth factor beta activates protein kinase ( ' i i i microvessels isolaled from immature rat brain.

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