By England 1958 Wolstenholme, G. E. W. ; O'Connor, Maeve, Ciba Foundation Symposium on the Biosynthesis of Terpenes and Sterols London
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Chapter 1 Chairman's commencing feedback (pages 1–3): Sir Robert Robinson
Chapter 2 Biogenesis and adjustments of Squalene (pages 4–19): Konrad Bloch
Chapter three Discovery and Elucidation of Mevalonic Acid (pages 20–45): Karl Folkers, Clifford H. Shunk, Bruce O. Linn, Franklin M. Robinson, Paul E. Wittreich, Jesse W. Huff, James L. Gilfillan and Helen R. Skeggs
Chapter four adjustments of ldl cholesterol Biosynthesis in Liver mobilephone Fractions from Rats in numerous Experimental stipulations (pages 46–61): Nancy L. R. Bucker
Chapter five The Enzymic Synthesis of Branched?Chain Acids (pages 62–74): M. J. Coon, F. P. Kupiecki, E. E. Dekker, M. J. Schlesinger and Alice Del Campillo
Chapter 6 The Biosynthesis of ??Hydroxy???Methyl?Glutaryl Coenzyme a and its Conversion to Mevalonic Acid (pages 75–94): Harry Rudney
Chapter 7 New facets of Acetate Incorporation into Isoprenoid Precursors (pages 95–118): F. Lynen, H. Eggerer, U. Henning, J. Knappe, I. Kessel and E. Ringelmann
Chapter eight The Mechanism of a Rearrangement happening in the course of Biosynthesis of ldl cholesterol (pages 119–184): J. W. Cornforth, Rita H. Cornforth, Marjorie G. Horning, A. Pelter and G. Popjak
Chapter nine Semi?, Mono?, Sesqui?, and Triterpenes as ldl cholesterol Precursors (pages 135–147): O. Isler, R. Ruegg, G. Saucy, J. Wursch, ok. F. Gey and A. Pletscher
Chapter 10 Biosynthesis of Squalene and of ldl cholesterol from Mevalonic Acid (pages 148–172): G. Popjak
Chapter eleven Biosynthesis of Yeast Sterols and the education of 14C?Labelled nutrition D2 (pages 173–184): E. Kodicek
Chapter 12 Bile Acids: Formation and Metabolism (pages 185–205): Sune Bergstrom
Chapter thirteen Species comparability as an relief within the learn of the method Sterols > Bile Salts (pages 206–216): G. A. D. Haslewood
Chapter 14 a few features of Acid?Catalysed Cyclizations of Terpenoid Polyenes (pages 217–230): A. Eschenmoser, Dorothee Felix, M. intestine, J. Meier and P. Stadler
Chapter 15 Biogenesis of Terpenes in Moulds and better vegetation (pages 231–244): D. Arigoni
Chapter sixteen The Biosynthesis of Terpenoid Compounds in Fungi (pages 245–266): A. J. Birch and Herchel Smith
Chapter 17 The Biosynthesis of Carotenoids through Micro?Organisms (pages 267–278): E. C. Grob
Chapter 18 A comparability of the Incorporation of Labelled CO2, Acetate and Mevalonate into Carotenoids in a couple of Carotenogenic structures (pages 279–301): T. W. Goodwin
Chapter 19 Chairman's remaining feedback (page 302):
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Additional resources for Ciba Foundation Symposium - Biosynthesis of Terpenes and Sterols
TCHEN,T. T. (1957). J. Amer. Chem. ,79,6345. WOLF,D. , HOFFMAN, C. , ALDRICH, P. , SKEGGS, H. , WRIGHT, L. , and FOLKERS, K. (1956). J. Amer. chem. , 78,&99. WOLF,D. , HOFFMAN, C. , ALDRICH, P. , SKEGGS, H. , WRIGHT, L. , and FOLKERS, K. (1957). J. Amer. chem. ,79, 1486. WRIGHT,L. , CRESSON, E. , SKEGGS, H. , MACRAE,G. D. , HOFFMAN, C. , WOLF,D. , and FOLKERS, K. (1956). J. Amer. 78,5273. chem. , DISCUSSION Grob: Hauge and Novak suggested that orotic acid may be an active compound of vitamin B13.
78,&99. WOLF,D. , HOFFMAN, C. , ALDRICH, P. , SKEGGS, H. , WRIGHT, L. , and FOLKERS, K. (1957). J. Amer. chem. ,79, 1486. WRIGHT,L. , CRESSON, E. , SKEGGS, H. , MACRAE,G. D. , HOFFMAN, C. , WOLF,D. , and FOLKERS, K. (1956). J. Amer. 78,5273. chem. , DISCUSSION Grob: Hauge and Novak suggested that orotic acid may be an active compound of vitamin B13. Have you found any orotic acid in your preparations and do you know if there is any relation between mevalonic acid and orotic acid ? Folkers: We did not look for orotic acid in our concentrates.
It appeared to us that our vitamin B,, concentrates were really multicomponent mixtures or were concentrates which could contain several physiologically active compounds, as 20 DISCOVERY AND ELUCIDATION OF MEVALONICACID 21 well as numerous inert substances. The nature of the process for preparing these concentrates led us to suspect the presence of lipoic acid, and a countercurrent distribution (CCD) experiment was planned for the purification of the lipoic acid component, which could be shown t o be present by microbiological assay.