Current Views of Fatty Acid Oxidation and Ketogenesis: From by Isabelle Cohen, Jean Girard (auth.), Patti A. Quant, Simon

By Isabelle Cohen, Jean Girard (auth.), Patti A. Quant, Simon Eaton (eds.)

This e-book brings jointly biochemical, genetic, molecular biology, and medical ways to the examine of fatty acid oxidation. together with present learn from many of the significant teams operating during this box, it presents a multi-disciplinary method of the topic and an up to date assessment of the latest advancements and debates.

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35 suggesting that trypsin at a concentration of 10µ g/mL has no effect on CPT-I activity. Their data is presented as percent activity as a function of exposure time to trypsin with no indication of the specific activity of the enzyme before Topology of Hepatic Mitochondrial Carnitine Palmitoyltransferase I 35 36 K. Kashfi and G. A. Cook trypsin treatment. In our studies presented in Fig. 4, it is interesting to note that if the isolation medium was changed from 250mM sucrose to 150mM KC1, then loss of CPTI activity as a function of exposure time to trypsin was much faster and also greater.

1990) Inhibition of Mitochondrial Carnitine Palmitoyltransferases by Adriamycin and Adriamycin Analogues. Biochem. Pharmacol. 40, 1441–1448. 29. A. K. (1969) Conditions for the self-catalysed inactivation of carnitine acetyltransferase. A novel form of enzyme inhibition. Biochem. J. 111, 225–235. 30. W. A. (1987) Effect of starvation and diabetes on the sensitivity of carnitine palmitoyltransferase I to inhibition by 4-hydroxyphenylglyoxylate. Biochem. J. 243, 405–412. 31. L. A.

1992) Biochem J 286, 637–640 Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase. G. A. (1997) Biochem J 323, 7 1 1 – 7 1 8 Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane. Fraser, F. A. (1998) Biochem J 329, 225–229 Enrichment of carnitine palmitoyl transferases I and I I in the contact sites of rat liver mitochondria. W. D. (1993) J Biol Chem 268, 5817–5822 Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmiloyltransferase I.

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